San Francisco are tipped to cover as they keep their perfect record intact.
The 49ers continue to deal with injuries, but they are off to a flying start and the offense is rolling after five weeks of the season.
Washington, on the other hand, just contrived to tie a game with the Giants that was theirs for the taking, and they head to Santa Clara without a win on the road this season.
Key Numbers – Can 49ers Take Their Record To 6-0?
- San Francisco 49ers are unbeaten after 5 games
- San Francisco 49ers have covered in 4 of their five games
- Washington Commanders are 0-2 on the road so far this season
- The Over has cashed in 7 of the 10 games involving either team
49ers Lead All-Time Head-To-Head; Won Last Meeting
- San Francisco 49ers lead the all-time series 23-12-1
- San Francisco 49ers won 27-10 when the two teams last met in December 2023
Washington Commanders 1-3-1 After Embarrassing Tie
Washington head to California on the back on an embarrassing finish to the game against New York that left them still seeking a second win.
The Commanders opened the season with back-to-back road games against division opponents, and came up short in both of them.
They were beaten 24-22 in Philadelphia, before heading to Dallas for a 37-20 defeat at the hands of the Cowboys.
Washington finally got off the mark with a 33-31 upset of Seattle at home, but quickly returned to losing ways as they fell 30-13 to Indianapolis.
The Commanders appeared poised to rebound from that loss when they marched into field goal range in overtime against the Giants last Sunday, but they made a complete mess of their clock management to allow time to expire with the teams locked at 20-20.
San Francisco 49ers Boast Perfect 5-0 Record
San Francisco enter this matchup having maintained their perfect record with another big division win last weekend.
The 49ers kicked off their campaign in Australia, where they beat NFC West rivals, and Super Bowl favourites, the Los Angeles Rams, 27-7.
They backed that up in their home opener as they beat Miami 35-13, and they then notched another division win a week later as they downed Arizona 36-30.
San Francisco made it four-in-a-row with a 24-14 victory over Denver, setting themselves up for a big trip to face defending champions Seattle last weekend.
The 49ers ran out winners in that big NFC West clash too, as they edged the Seahawks 32-29.