Alexander Zverev Zverev has been the best performer at the Grand Slams this year, reaching the semifinals of the Australian Open, winning the French Open and finishing runner-up at Wimbledon. Now the top seed, the German is a fantastic hard-court player and will be one of the main players to watch in New York.
Carlos Alcaraz
Alcaraz, returning from a lengthy injury break, would ideally have been the firm favourite for the title in Sinner's absence. However, the long layoff raises questions about his fitness, and his early-round performances will be closely watched to see how his body holds up before he can be seriously backed for a deep run.
Novak Djokovic
Age has taken a noticeable toll on both Djokovic's body and his level, but his pedigree simply cannot be ignored. The 24-time Grand Slam champion and multiple-time US Open winner remains a serious contender and should still be in the mix for the title.
Daniil Medvedev
Medvedev is not in optimal form right now, but his pedigree on American hard courts means he cannot be taken lightly. A former US Open champion and world No. 1, he has the experience and game to become a major factor if he can rediscover his best level.
Taylor Fritz
Fritz arrives with strong preparation behind him, having won the title in Washington before making a deep run in Cincinnati. Fritz has long chased a Grand Slam breakthrough, particularly at the US Open, where he has previously finished runner-up. With Sinner absent and question marks surrounding Alcaraz and Djokovic, this could be his opportunity to make a major statement.